In recent years, transfusion of platelets obtained from individual donors has increased markedly concurrent with the availability of cell separators. In order to evaluate the effects of plateletpheresis on the platelet function of 26 healthy
donors,
ADP-, epinephrine-, collagen-, and reistocetin-induced platelet aggregation before and after plateletpheresis were investigated by densitometric aggregometer.
Abnormal aggregation function was disclosed after plateletpheresis in 3 cases for ADP, 7 cases for epinephrine, and 1 case for collagen. In total 8 of 26 donors, aggegation function was- changed to abnormal, of which 1 case recovered at 24 and 48
hours
after plateletpheresis and in the other 1 case the abnormal function persisted. The remaining 6 cases were not have followed up.
D-dimer test was negative after plateletpheresis in all cases.
These data suggest that abnormal platelet function could occur after plateletpheresis in donors and might persist in some cases. The search for the causes and clinical implications is remained to be elucidated.
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